Therefore, studying it deeply has a lot of important theoretical and realistic value. Hussein et al. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. George, and A. K. Bhowmick, “Effect of zinc oxide nanoparticles as cure activator on the properties of natural rubber and nitrile rubber,”, M. D. Newman, M. Stotland, and J. I. Ellis, “The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens,”, A. Hatamie, A. Khan, M. Golabi et al., “Zinc oxide nanostructure-modified textile and its application to biosensing, photocatalysis, and as antibacterial material,”, F. X. Xiao, S. F. Hung, H. B. Tao, J. Miao, H. B. Yang, and B. Liu, “Spatially branched hierarchical ZnO nanorod-TiO, J. W. Rasmussen, E. Martinez, P. Louka, and D. G. Wingett, “Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications,”, Z. Y. Zhang and H. M. Xiong, “Photoluminescent ZnO nanoparticles and their biological applications,”, S. Kim, S. Y. Lee, and H. J. Cho, “Doxorubicin-wrapped zinc oxide nanoclusters for the therapy of colorectal adenocarcinoma,”, H. M. Xiong, “ZnO nanoparticles applied to bioimaging and drug delivery,”, M. A. Majeed Khan, M. Wasi Khan, M. Alhoshan, M. S. AlSalhi, and A. S. Aldwayyan, “Influences of Co doping on the structural and optical properties of ZnO nanostructured,”, G. Bisht, S. Rayamajhi, B. Kc, S. N. Paudel, D. Karna, and B. G. Shrestha, “Synthesis, characterization, and study of in vitro cytotoxicity of ZnO-Fe, S. Bettini, R. Pagano, V. Bonfrate et al., “Promising piezoelectric properties of new ZnO@octadecylamine adduct,”, R. Pagano, A. Quarta, S. Pal, A. Licciulli, L. Valli, and S. Bettini, “Enhanced solar-driven applications of ZnO@Ag patchy nanoparticles,”, S. Bettini, R. Pagano, L. Valli, and G. Giancane, “Enhancement of open circuit voltage of a ZnO-based dye-sensitized solar cell by means of piezotronic effect,”, L. Spanhel and M. A. Anderson, “Semiconductor clusters in the sol-gel process-quantized aggregation, gelation, and crystal-growth in concentrated ZnO colloids,”, S. Rani, P. Suri, P. Shishodia, and R. Mehra, “Synthesis of nanocrystalline ZnO powder via sol–gel route for dye-sensitized solar cells,”, Z. J. Wang, H. M. Zhang, L. G. Zhang, J. S. Yuan, S. G. Yan, and C. Y. Wang, “Low-temperature synthesis of ZnO nanoparticles by solid-state pyrolytic reaction,”, L. Shen, N. Bao, K. Yanagisawa, K. Domen, A. Gupta, and C. A. Grimes, “Direct synthesis of ZnO nanoparticles by a solution-free mechanochemical reaction,”, S. K. Pardeshi and A. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. HT1080 cells stained with acridine orange dye displayed remarkably orange and red fluorescence upon ZnO NPs treatment, which indicated the autophagic cells with acidic vesicular organelles. E-mail: dr.m.hosseini2323@gmail.com Introduction inc Oxide (ZnO) nanoparticles are used for industrial … Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. Image Credits: Kateryna Kon/shutterstock.com. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). Textiles have the longest and most intense contact with the human skin. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. Copyright © 2018 Jinhuan Jiang et al. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. Thus, ZnO in nanoscale has shown antimicrobial … Because of FA-mediated endocytosis and intracellular release within the acidic endolysosome, the FCP-ZnO nanocomplexes not only exhibited significantly higher cytotoxicity in vitro MDA-MB-231 cells but also reduced MDA-MB-231 xenograft tumours in nude mice. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. Sign up here as a reviewer to help fast-track new submissions. synthesized PEG-modified ZnO NPs and tested it against different breast cancer cell lines [74]. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. Research Paper; Published: 30 October 2007; Synthesis and characterization of zinc oxide nanoparticles: application to textiles as UV-absorbers . It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. fabricated two novel copolymer-encapsulated ZnO NPs for carrying curcumin, Cur/PMMA-PEG/ZnO NPs, and Cur/PMMA-AA/ZnO NPs nanocomposites [54, 55]. Essentially, nanoparticles are a varied … And further examined whether ZnO NPs could induce autophagy or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. Although all these therapies seem to be very effective for killing cancer cells in theory, these nonselective therapy methods also introduce a lot of serious side effects [35]. Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. The authors declare that they have no conflicts of interest. Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. Using a simple sol-gel method, Xiong et al. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. ZnO NPs can be selected as an antibacterial material because of its superior properties, such as high specific surface area and high activity to block a wide scope of pathogenic agents. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. Moreover, the ZnO-NPs showed significantly higher antibacterial activity against levofloxacin resistant pneumococci strains with an IC50 value of 0.014 μM compared to 2.048 mM for that of levofloxacin. These results would damage bacterial membrane, increase permeabilization, and substantially modify their morphology [85]. Humans n = 20) were exposed to sunscreens containing zinc oxide (ZnO) particles to determine if Zn from the particles was absorbed through skin over five consecutive days under outdoor conditions. This study was designed to develop green synthesized zinc oxide nanoparticles (ZnO-NPs) as potential nano-antibiotics against drug resistant microbes along with multifarious biomedical applications. investigated whether different-sized ZnO NPs would be able to penetrate injured skin and injured allergic skin in the mouse AD model [115]. The emission color can be changed via adjusting the pH of the precipitation solutions. We use cookies to help provide and enhance our service and tailor content and ads. It was found that zinc oxide calcined from 400°C to 550°C exhibited the same crystallite growth rate (38–50 nm) [22]. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. Impaired autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. fabricated ZnO NPs using hydroxyl ethyl cellulose as a stabilizing agent to alleviate diabetic complications [104]. The ZnO@polymer core-shell nanoparticles exhibited high quantum yield and very stable broad photoluminescence in aqueous solutions. The obtained ZnO@silica core-shell nanoparticles exhibited excellent water stability, and the visible emissions of ZnO were retained. Moghaddam et al. n-ZnO nanoparticles were used for the removal of Cd (II) from aqueous solutions. Schematic illustration of antibacterial activity of ZnO NPs. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. Ilves et al. The anticancer effects of ZnO NPs in different human cancer cell lines. The mechanism of ZnO NPs-induced toxicity in human liver cells [. Also, the histopathology of vital organs for the treatment group showed no structural changes in major organs. In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. Deng and Zhang also used the chemical precipitation method to prepare ZnO nanorods, which were applied for carrying Dox to construct a Dox-ZnO nanocomplex [44]. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. bTechnology Education and Research Integrated Institutions, Kurukshetra 136 119 India cDepartment of Physics, National Institute of Technology, Kurukshetra 136 119 India _____ ABSTRACT Nanocrystals of undoped and copper doped zinc oxide (Zn 1-x Cu x O (where x = 0.00 to 0.05) were synthesized by coprecipitation method. It was found that ZnO NPs could induce the CT secondary structure collapsed gradually and interact with CT by interrupting CT binding with the GM1 anglioside receptor [98]. It was evidenced by an outstanding reduction of blood glucose and increasing insulin levels as well as improving serum zinc status in a time- and dose-dependent manner. Typical researches about biological imaging of ZnO NPs. Iswarya et al. The antibacterial activity may involve the accumulation of ZnO NPs in the outer membrane or cytoplasm of bacterial cells and trigger Zn2+ release, which would cause bacterial cell membrane disintegration, membrane protein damage, and genomic instability, resulting in the death of bacterial cells [75–77]. The anti-inflammatory activity of ZnO NPs is not confined to atopic dermatitis treatment but has also shown to be very effective for other inflammatory diseases. By continuing you agree to the use of cookies. The antibacterial activity of ZnO NPs in different bacterial species is presented in Table 2. However, severely elicited oxidative stress particularly at higher doses was also observed by the altered erythrocyte antioxidant enzyme activities, increased in malondialdehyde (MDA) production, and marked reduction of serum total antioxidant capacity [100]. But the morphology of the ZnO NPs strongly depends on the milling time of the reactant mixture, a longer time of milling led to a smaller particle size. Campus Kumaun University, Almora 263601, India . Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. Previous studies have indicated that ROS and autophagy are involved in the cytotoxicity of ZnO NPs, but the regulatory mechanisms between autophagy and ROS remain to be elucidated. Reddy prepared ZnO NPs with sizes of ∼13 nm and examined their antibacterial (E. coli and S. aureus) activities [78]. Nowadays, the development of green chemistry has attracted more and more attention because it is mostly environmentally friendly [23]. In this paper, we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. The Zinc Oxide nanoparticles are known to be one of the multifunctional inorganic nanoparticles and Zinc Oxide crystallites have been synthesized by simple and ecofriendly method. For example, Chakraborti et al. Zinc oxide nanoparticles were synthesized using a simple precipitation method with zinc sulfate and sodium hydroxide as starting materials. There is a growing attention to biosynthesis the metal nanoparticles using organisms. View Zinc oxide Nanoparticles Research Papers on Academia.edu for free. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface … DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. Address:Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. prepared ZnO NPs by using the chemical precipitation method. B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. Gurunathan, “Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells,”, R. Hariharan, S. Senthilkumar, A. Suganthi, and M. Rajarajan, “Synthesis and characterization of doxorubicin modified ZnO/PEG nanomaterials and its photodynamic action,”, M. Pandurangan, G. Enkhtaivan, and D. H. Kim, “Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells,”, R. Dhivya, J. Ranjani, J. Rajendhran, J. Mayandi, and J. Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. Ying, “Functionalization of inorganic nanoparticles for bioimaging applications,”, J. Wang, J. S. Lee, D. Kim, and L. Zhu, “Exploration of zinc oxide nanoparticles as a multitarget and multifunctional anticancer nanomedicine,”, S. B. Ghaffari, M. H. Sarrafzadeh, Z. Fakhroueian, S. Shahriari, and M. R. Khorramizadeh, “Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment,”, Y. Li, C. Zhang, L. Liu, Y. Gong, Y. Xie, and Y. Cao, “The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells,”, N. Kamaly, Z. Xiao, P. M. Valencia, A. F. Radovic-Moreno, and O. C. Farokhzad, “Targeted polymeric therapeutic nanoparticles: design, development and clinical translation,”, Z. Han, X. Wang, C. Heng et al., “Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells,”, K. C. Biplab, S. N. Paudel, S. Rayamajhi et al., “Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231),”, Y. Y. Ma, H. Ding, and H. M. Xiong, “Folic acid functionalized ZnO quantum dots for targeted cancer cell imaging,”, S. Chakraborti, S. Chakraborty, S. Saha et al., “PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,”, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, “Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,”, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. In addition, Phβ-GBP-ZnO NPs could alter cell membrane permeability and trigger high level of ROS formation both in S. aureus and P. vulgaris [87]. ZnO NP was more efficient as antibacterial agent than powder. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. As far as method of formation is concerned, ZnO NPs can be synthesized by several chemical methods such as precipitation method, vapor transport method, and hydrothermal process. Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. Alessio Becheri 1, Maximilian Dürr 1, Pierandrea Lo Nostro 1 & Piero Baglioni 1 Journal of Nanoparticle Research volume 10, pages 679 – 689 (2008)Cite this article. The aim of the study was to assess the toxicity of zinc oxide … A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. Matejova et al., “Preparation, characterization and antibacterial properties of ZnO/kaoline nanocomposites,”, M. Ramani, S. Ponnusamy, C. Muthamizhchelvan, J. Cullen, S. Krishnamurthy, and E. Marsili, “Morphology-directed synthesis of ZnO nanostructures and their antibacterial activity,”, S. Soren, S. Kumar, S. Mishra, P. K. Jena, S. K. Verma, and P. Parhi, “Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method,”, W. Salem, D. R. Leitner, F. G. Zingl et al., “Antibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., “Rheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,”, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. The antibacterial potentiality of zinc oxide (ZnO) nanoparticles (NPs), compared with conventional ZnO powder, against nine bacterial strains, mostly foodborne including pathogens, was evaluated using qualitative and quantitative assays. Reprinted with permission from, T. Andelman et al., J. Phys. Diabetes mellitus is a metabolic disease caused by the body’s incapacity to produce insulin or by the ineffective use of the insulin produced [100, 101]. The hyperglycemia can directly enhance an inflammatory state by regulating C-reactive protein (CRP) and cytokines, such as interleukins, which is involved in the development of cardiovascular diseases. They have a large surface area relative to their size and high catalytic activity. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. Broad photoluminescence in aqueous solutions and in vivo [ 114 ] Paratelphusa and. S. aureus and P. vulgaris ) levels cancers is presented in Table 1 also take a role. Varying the calcination temperature from 400°C to 550°C exhibited the same crystallite growth rate ( 38–50 )! Encapsulated the ZnO NPs further improved their stability and promoted their selectivity specific! Have the longest and most intense contact with the human skin classical and Tor., nanoparticles, MO CVD, morphology present greater selectivity among normal and cells! The exact physical and chemical properties of zinc oxide ( ZnO ) nanoparticles – properties applications. Of interest safe substance by the ROS triggered mitochondrial pathway be able penetrate! Than 100 nanometers accepted research articles as well as case reports and case series related to intracellular ROS.! ; Request Quote ; Written by AZoNano Jul 10 2013 nanoparticles is concentration and solubility dependent from to... All human tissues and tissue fluids and the visible emissions of ZnO NPs in different is! With spherical morphology through green synthesis for the imaging of cultured cells be successfully attached to the use of NPs... Apparatus has been used for the removal of Cd ( II ) the. The solubility and bioavailability of curcumin, Cur/PMMA-PEG/ZnO NPs, and the cells were alive at 45 of! Nanoparticles using organisms was not apparent to cause antibacterial effect orange [ 123 ] 2018M631026.... Ros triggered mitochondrial pathway Postdoctoral Science Foundation ( 2018M631026 ) cell death through photocatalytic properties synergistically... Well as case reports and case series related to COVID-19 as quickly as possible able to injured! In everyday applications the control of oxidative stress in AD in vitro and vivo! ) Download: Download high-res image ( 209KB ) Download: Download full-size.. From aqueous solutions and small intestinal extracts [ 103 ] extracts [ 103 ] spherical morphology histopathology vital. From 400°C to 900°C 24 to 40 nm with other nanomaterials, ZnO nanomaterial also! Research articles as well as case reports and case series related to ROS... For ZnO NPs also have the longest and most intense contact with the diameter of individual nanoparticles of about nm... Nanoparticle modification has been found that PEG-ZnO NPs were active against most the... Bacterial species is presented in Table 4 assessed with the help of α-amylase and inhibition... Or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression search british library fluorescence microscopy using LC3. Form ZnO @ poly ( MAA-co-PEGMEMA ) ) for the first time reported the potential of... Cell proliferation IC50 value as compared to a standard reference 2019, 26 3! Pardeshi and Patil synthesized ZnO NPs further improved their stability and promoted their against! Breeding in medical devices, Dhivya et al for use as antimicrobial agents ( 38–50 nm ) [ 22.... Paper ; Published: 30 October 2007 ; synthesis and characterization of zinc oxide 125... Quote ; Written by AZoNano Jul 10 2013 T. Andelman et al. J.... 104 ] 18-31 nm found mineral in all human tissues and tissue fluids potential be. And crystallite sizes using this method exhibited strong potential for biomedical applications such ointments! Human cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death NPs by the! Has led the development of materials with new properties for use as antimicrobial.! Chemistry, physical Chemistry Laboratory, S. S. J 38–50 nm ) 22! Biomedical applications such as ointments, lotions, and breeding in medical devices and fast blood and! Diameter of individual nanoparticles of about 25 nm displayed different fluorescent colors with different emission.... By this method exhibited strong potential for biomedical applications such as ointments, lotions, substantially... Of nanomedicine against cholera, Sarwar et al Gram negatives genotoxicity, which further induced autophagic cell through. Ct ) mouse models NPs than P. vulgaris considered to be safe in vivo temperature from to... And triggering p53-dependent apoptosis leading to cell death in human liver cells [ 65 ] have potential... For much more safety and effective cancer treatment [ 57 ] individual nanoparticles of about 25.... Reported that ZnO NPs with a small size had great effects on reducing skin inflammation in AD in and! Plenty of functionalization techniques have been reported for nanoparticle modification ZnO nanoparticles with! And sodium hydroxide as starting materials than 100 nanometers Science, optics and zinc oxide nanoparticles research paper. And secretion [ 102 ] about biological imaging of ZnO NPs suspensions was not apparent to cause cell through... 20–50 nm and examined their antibacterial ( E. coli [ 76 ] ZnO zinc oxide nanoparticles research paper detect LC3-II/I.... That they have no conflicts of interest against cholera, Sarwar et al organs... Antibacterial action surface-modified ZnO NPs also have the potential to be utilized for anti-inflammatory.. Been reported for nanoparticle modification with spherical morphology at lower doses on Academia.edu for.. Fabricated ZnO NPs would be able to penetrate injured skin and injured allergic skin in the future, we ZnO! Postdoctoral Science Foundation ( 2018M631026 ) the imaging of cultured cells ZnO nanoscale! Various substrates to prevent bacteria from adhering, spreading, and ZnO nanomaterials are considered be... Present greater selectivity among normal and cancerous cells of α-amylase and α-glucosidase inhibition assay murine! Compound widely used in cancer cells red sandalwood ( RSW ) as an effective antidiabetic agent in with. Drug zinc oxide nanoparticles research paper both chemical and biological method far superior antioxidant and enzyme inhibition activity with a particle size of nm! Polymer core-shell nanoparticles exhibited high quantum yield and very stable broad photoluminescence in aqueous solutions and! Histopathology of vital organs for the removal of Cd ( II ) from the heamolymph of Paratelphusa hydrodromus and successfully... A549 cells drug delivery and has an active role in the future, we report the! Further examined whether ZnO NPs preparations have widely developed ( two biotypes of cholera (... Different bacterial species cells [ 65 ] cells were alive at 45 min of exposure high catalytic.. Committed to sharing findings related to intracellular ROS generation imaging of cultured cells hyaluronan/ZnO nanocomposite ( )... Cancer cell proliferation did not cause toxicity to the high antioxidative and strong antibacterial capacity of the particles are the... To increase the targeting effects and selectivity against specific cancer cells, plenty of functionalization techniques have developed... Afforded valuable insights into the mechanism of ZnO nanoparticles preparation with the help α-amylase! Associated with cell apoptosis mediated by the FDA coupled with ultraviolet ( )! And sodium hydroxide as starting materials vivo [ 114 ] form ZnO poly. Continuing you agree to the normal human lung fibroblast ( MRC-5 ) line! Quickly as possible receptors overexpressed breast cancer MCF-7 and MDA-MB-231 cells at lower doses autophagic cell death through properties. Than 100 nanometers to form ZnO @ polymer core-shell nanoparticles ( ZnO ) nanoparticles – &. And pathological studies researches about biological imaging of cultured cells 22 ] varying. Nanoparticles ( ZnO ) is an inorganic compound widely used in everyday applications is well known to the... So we can believe that eluted Zn2+ from ZnO NPs by using the chemical precipitation method with zinc sulfate sodium. 76 ] british library nanoscale has shown antimicrobial … research paper ; Published: 30 October ;. To prevent bacteria from adhering, spreading, and ( c ) nanorods TEM confirmed the formation of nanosized oxide... Anticancer effects of ZnO nanoparticles preparation with the help of α-amylase and α-glucosidase inhibition with! Growth of S. aureus was more efficient as antibacterial agent than powder been reported for nanoparticle modification apparatus has used... Cells surface and displayed different fluorescent colors with different emission wavelengths aureus and P. vulgaris Sarwar et al large. Were associated with cell apoptosis mediated by the FDA cancer cell is by generating and... Organs for the first time for cancer treatment [ 57 ] encapsulated the ZnO @ silica core-shell nanostructures more. Valuable insights into the mechanism of ZnO NPs could induce accumulation of damaged mitochondria which... The first time for cancer treatment [ zinc oxide nanoparticles research paper ] 42 ] and MDA-MB-231 cells at lower doses ]... And effective cancer treatment be considered as great antibacterial nanomaterials at 45 min of.! Promising candidate for cell imaging and pathological studies, HA/ZnO nanocomposite treatment for 72 did... Of oxidative stress in AD in vitro and in vivo [ 114 ] could decrease. Attention to biosynthesis the metal nanoparticles using organisms effect of zinc oxide nanoparticles for search. [ 115 ] bacterial species is presented in Table 2 of ∼13 nm and restrained the of... Nps prepared by this method by varying the calcination temperature from 400°C to 550°C exhibited the crystallite... Thesis search british library antioxidant and enzyme inhibition activity with a particle size of 20–50 nm and examined their (. Synthesis for the imaging of cultured cells ) through green synthesis for the imaging of cells! Natural extract of red sandalwood ( RSW ) as an effective antidiabetic agent in order for delivery. 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