Side effects of DIM supplements are common and may include headaches, dehydration, as well as joint pain, aching, or cracking. After all, any supplement, even if it’s all natural, may have negative side effects. DIM – Diindolylmethane is an androgen antagonist! The data from this study indicated that DIM is safe, with no significant side effects found, even with DIM at a dose 10 times higher than that currently used in practice. DIM has also been shown to favorably alter the ratios of “good” to “bad” estrogen. Higher doses (greater than 100mg) of isolated pure DIM can saturate tissues and block androgen (e.g. Diindolylmethane Side Effects. Keep in mind that the safety profile of DIM is relatively unknown, given the lack of well-designed clinical studies. In light of this, are there any DIM adverse consequences? Diindolylmethane is formed in the body from plant substances contained in “cruciferous” vegetables such as cabbage, Brussels sprouts, cauliflower, and broccoli. Diindolylmethane Side Effects Rash, nausea, vomiting, headache, arthralgia and hot flashes have been reported. Some common side effects that occur following the usage of DIM include a rash with eosinophilia as well as central serous chorioretinopathy . Learn more about Diindolylmethane uses, benefits, side effects, interactions, safety concerns, and effectiveness. WebMd.com claims DIM is most likely safe. Diindolylmethane (DIM) reduces the level of "bad estrogen" (16-hydroxyestrone estrogen metabolites) while increasing "good" estrogen (2-hydroxyestrone estrogen metabolites). They have different amounts of DIM per capsule (200 or 250mg), and the DIM 250 Complex also contains an array of different supportive ingredients designed to maximize usefulness for use during menopause, including various vegetable powders, Broccoli seed extract, Vitamin D-3, and herbal Dong Quai. DIM side effects caused by hyponatremia are far more likely to be experienced by the elderly. Side effects mentioned in DIM Elite reviews on Amazon include an irregular menstrual cycle, insomnia, increased acne, and hair loss. But are the possible benefits worth the risk? Diindolylmethane may cause a decrease in the amount of sodium in the body . Nature's Way DIM Plus is used for estrogen metabolism which is the breakdown of estrogen in the liver attempting to eradicate it. Research seems to show associations between hyponatremia and osteoporosis. Notably, falling down is the most prevalent cause of accidental death among people 65 and older. Studies suggest it protects the body from xenoestrogens, compounds that mimic and intensify the effects of estrogen. DIM Supplement Side Effects and Dosage. While there are promising benefits that can come with taking DIM, there are some potential side effects to take note. DIM possesses hormone-modulating effects. It may do so in several ways. testosterone and dihydrotestosterone) receptors and inhibit the protein synthesis induced by the anabolic effects of androgens. DIM side effects. DIM blocks the effects of testosterone. It further confirmed results and safety reported from previous studies in adult humans and the adult animal model. Hello Marva, DIM 200, and DIM 250 Complex are different supplements. Side Effects. When taken correctly in the small amounts found in foods, diindolymethane is likely safe. Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. 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